[HTML][HTML] Transcriptomic responses in the fish intestine
SAM Martin, CE Dehler, E Król - Developmental & Comparative …, 2016 - Elsevier
The intestine, being a multifunctional organ central to both nutrient uptake, pathogen
recognition and regulating the intestinal microbiome, has been subjected to intense …
recognition and regulating the intestinal microbiome, has been subjected to intense …
RNA sequencing for research and diagnostics in clinical oncology
Molecular diagnostics is becoming one of the major drivers of personalized oncology. With
hundreds of different approved anticancer drugs and regimens of their administration …
hundreds of different approved anticancer drugs and regimens of their administration …
[HTML][HTML] Single-nuclei RNA sequencing assessment of the hepatic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
Background and Aims Characterization of cell specific transcriptional responses to
hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single …
hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single …
H3K4me3, H3K9ac, H3K27ac, H3K27me3 and H3K9me3 histone tags suggest distinct regulatory evolution of open and condensed chromatin landmarks
Background: Transposons are selfish genetic elements that self-reproduce in host DNA.
They were active during evolutionary history and now occupy almost half of mammalian …
They were active during evolutionary history and now occupy almost half of mammalian …
Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the
development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the …
development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the …
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism
Abstract 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental
contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor …
contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor …
Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis
We have previously shown that in response to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-
elicited NAFLD progression, central carbon, glutaminolysis, and serine/folate metabolism …
elicited NAFLD progression, central carbon, glutaminolysis, and serine/folate metabolism …
Bioinformatic workflows for deriving transcriptomic points of departure: current status, data gaps, and research priorities
There is a pressing need to increase the efficiency and reliability of toxicological safety
assessment for protecting human health and the environment. Although conventional …
assessment for protecting human health and the environment. Although conventional …
Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
The environmental contaminant 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) induces
hepatic steatosis mediated by the aryl hydrocarbon receptor. To further characterize TCDD …
hepatic steatosis mediated by the aryl hydrocarbon receptor. To further characterize TCDD …
2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice
Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of
circadian clock regulators, however the impact on clock-controlled metabolism has not been …
circadian clock regulators, however the impact on clock-controlled metabolism has not been …