It is widely recognized that the vasculature of the tumor is inadequate to meet the demands
of the growing mass. The malformed vasculature is at least in part responsible for regions of …

Malignant gliomas are relatively uncommon but lethal cancers. Despite recent research
efforts in cancer therapy, the prognosis of patients with malignant gliomas has remained …

Some proteins undergo posttranslational modification by the addition of an isoprenyl lipid
(farnesyl-or geranylgeranyl-isoprenoid) to a cysteine residue proximal to the C terminus …

Rho GTPases are key molecular switches controlling the transduction of external signals to
cytoplasmic and nuclear effectors. In the last few years, the development of genetic and …

Activated Ras has been found in many types of cancer. However, the mechanism underlying
Ras-promoted tumor metastasis remains unclear. We demonstrate here that activated Ras …

RAS has been shown to increase radiation resistance. Upstream and downstream pathways
from RAS could thus be targets for manipulation of radiosensitivity. EGFR expression and …

Background Glioblastoma is the most common malignant brain tumor in human adults.
Despite several improvements in resective as well as adjuvant therapy over the last …

Integrins are extracellular matrix receptors involved in tumour invasion and angiogenesis.
Although there is evidence that inhibiting integrins might enhance the efficiency of …

The presence of hypoxic areas in glioblastoma is an important determinant in tumor
response to therapy and, in particular, to radiotherapy. Here we have explored the …

Since radiation therapy remains a primary treatment modality for gliomas, the
radioresistance of glioma cells and targets to modify their radiation tolerance are of …