Free radical as a double-edged sword in disease: Deriving strategic opportunities for nanotherapeutics

L Zhu, M Luo, Y Zhang, F Fang, M Li, F An… - Coordination chemistry …, 2023 - Elsevier
Free radicals, usually containing one or more unpaired electrons, are extremely unstable
and highly reactive with other biological molecules. Recently, there has been increasing …

Antioxidative 0-dimensional nanodrugs overcome obstacles in AKI antioxidant therapy

Y Yang, Y Nan, Q Chen, Z Xiao, Y Zhang… - Journal of Materials …, 2023 - pubs.rsc.org
Acute kidney injury (AKI) is a commonly encountered syndrome associated with various
aetiologies and pathophysiological processes leading to enormous health risks and …

Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition

H Ma, X Zhang, L Liu, Y Huang, S Sun, K Chen… - Science …, 2023 - science.org
Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to
conflicts in free electron utilization, resulting in a lack of bioactivity of most near-infrared-II …

Fe-curcumin nanozyme-mediated reactive oxygen species scavenging and anti-inflammation for acute lung injury

R Yuan, Y Li, S Han, X Chen, J Chen, J He… - ACS central …, 2021 - ACS Publications
Pneumonia, such as acute lung injury (ALI), has been a type of lethal disease that is
generally caused by uncontrolled inflammatory response and excessive generation of …

Bioinspired integration of naturally occurring molecules towards universal and smart antibacterial coatings

L Yang, C Wang, L Li, F Zhu, X Ren… - Advanced Functional …, 2022 - Wiley Online Library
Surface‐independent smart antibacterial coatings with on‐demand antibiotics release
profiles have attracted increasing attention in medical instruments, antibiotics delivery …

Cu-GA-coordination polymer nanozymes with triple enzymatic activity for wound disinfection and accelerated wound healing

H Tian, J Yan, W Zhang, H Li, S Jiang, H Qian, X Chen… - Acta Biomaterialia, 2023 - Elsevier
During the past few years, bacterial infection and oxidative stress have become important
issues for wound healing. However, the emergence of numerous drug-resistant superbugs …

Radicals scavenging MOFs enabling targeting delivery of siRNA for rheumatoid arthritis therapy

L Guo, S Zhong, P Liu, M Guo, J Ding, W Zhou - Small, 2022 - Wiley Online Library
Macrophages play essential roles in the progression of rheumatoid arthritis (RA), which are
polarized into the pro‐inflammatory M1 phenotype with significant oxidative stress and …

Natural polyphenolic nanodots for Alzheimer's disease treatment

P Yang, Q Huang, J Zhang, Y Li, H Gao… - Advanced …, 2024 - Wiley Online Library
The abnormal amyloid‐β accumulation is essential and obbligato in Alzheimer's disease
pathogenesis and natural polyphenols exhibit great potential as amyloid aggregation …

Synergistic antimicrobial and antibiofilm nanoparticles assembled from naturally occurring building blocks

H Li, J Zhang, L Yang, H Cao, Z Yang… - Advanced Functional …, 2023 - Wiley Online Library
Bacterial infections represent one of the serious human healthcare threats, and≈ 80% of
bacterial infections are related to biofilm. So far, there are extensive investigations on the …

Ultrasmall Coordination Polymer Nanodots Fe‐Quer Nanozymes for Preventing and Delaying the Development and Progression of Diabetic Retinopathy

S Gui, W Tang, Z Huang, X Wang, S Gui… - Advanced Functional …, 2023 - Wiley Online Library
Diabetic retinopathy (DR) is the most prevalent type of retinal vasculopathy and the most
widespread cause of preventable blindness in adults. Excessive increases in reactive …