β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial
agents for treating both Gram-negative and Gram-positive bacterial infections. The β-lactam …

The effectiveness of β-lactam antibiotics is increasingly influenced by serine β-lactamases
(SBLs) and metallo-β-lactamases (MBLs), which can hydrolyze β-lactam antibiotics. The …

A series of 2-aminothiazole sulfanilamide oximes were developed as new membrane active
antibacterial agents to conquer the microbial infection. Benzoyl derivative 10c was …

In an attempt to exploit the hydrolytic mechanism by which β-lactamases degrade
cephalosporins, we designed and synthesized a series of novel cephalosporin prodrugs …

New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …

The emergence and dissemination of metallo-β-lactamases (MBLs) producing
Enterobacterales is a great concern for public health due to the limited therapeutic options …

The production of β-lactamases by bacterial pathogens endangers antimicrobial therapy,
and new inhibitors for β-lactamases are urgently needed. We report the development of a …

Background/Objectives: Among various carbapenemases, New Delhi metallo-beta-
lactamases (NDMs) are recognized as the most powerful type capable of hydrolyzing all …

The most effective approach to mitigate the toxic effects of internal exposure of radiometals
to humans is metal–ligand (ML) chelation therapy. Thorium (Th)-induced carcinogenesis as …

The increasing prevalence of metallo‐β‐lactamase (MBL)‐expressing bacteria presents a
worrying trend in antibiotic resistance. MBLs rely on active site zinc ions for their hydrolytic …