The chemical treatment of cancer started with the realization that DNA damaging agents
such as mustard gas present notable antitumoural properties. Consequently, early drug …

Proliferating cells rely on the so-called DNA replication checkpoint to ensure orderly
completion of genome duplication, and its malfunction may lead to catastrophic genome …

Ewing sarcoma is an aggressive paediatric cancer of the bone and soft tissue. It results from
a chromosomal translocation, predominantly t (11; 22)(q24: q12), that fuses the N-terminal …

The DNA damage response (DDR) represents a complex network of proteins which detect
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …

Over the last decade the unravelling of the molecular mechanisms of the DNA damage
response pathways and of the genomic landscape of human tumors have paved the road to …

Many conventional chemotherapies used in cancer treatment exert their effect by inflicting
DNA damage. Highly proliferative tissues, as well as tumour cells, are particularly vulnerable …

Many cancer types are driven by oncogenic transcription factors that have been difficult to
drug. Transcriptional inhibitors, however, may offer inroads into targeting these cancers …

Simple Summary Since it was first described over two decades ago, the Alternative
Lengthening of Telomeres (ALT) pathway has been well accepted to hold clinical …

The development of metastatic cancer is a multistage process, which often requires decades
to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors …

The response to DNA replication stress in eukaryotes is under the control of the ataxia–
telangiectasia and Rad3-related (ATR) kinase. ATR responds to single-stranded (ss) DNA to …