Objective Diagnostic delay is high in acromegaly and leads to increased morbidity and
mortality. The aim of this study is to systematically assess the most prevalent clinical signs …

Objective Data on sex differences in acromegaly at the time of diagnosis vary considerably
between studies. Design A nationwide cohort study including all incident cases of …

Objective Investigate the changes in the characteristics of presentation, in patients with
acromegaly over a period of approximately half a century. Methods The medical records of …

Purpose Early diagnosis is a success factor for the prevention of long-term comorbidity and
premature death in patients with acromegaly, but large-scale data on the diagnostic process …

Objective Carpal tunnel syndrome (CTS) is common in patients with acromegaly, with a
reported prevalence of 19–64%. We studied CTS in a large national cohort of patients with …

Background: Acromegaly is a chronic disease caused by an abnormal secretion of growth
hormone (GH) by a pituitary adenoma, resulting in an increased circulating concentration of …

Purpose Oro-facial manifestations of acromegaly are among the earliest signs of the disease
and are reported by a significant number of patients at diagnosis. Despite this high …

The review assesses immunohistochemical findings of somatostatin receptors and of
metalloproteinases in different pituitary adenoma types and the significance of molecular …

Background Pituitary adenomas are benign brain tumors that cause considerable morbidity
and neurological symptoms. SOX9 as a regulatory transcriptional mediator affects normal …

Machine learning assisted diagnosis of acromegaly from facial photographs has been
proved feasible in recent years. According to our previous research, facial and limb changes …