SARS-CoV-2 triggering autoimmune diseases

L Mobasheri, MH Nasirpour, E Masoumi… - Cytokine, 2022 - Elsevier
Autoimmunity, hyperstimulation of the immune system, can be caused by a variety of
reasons. Viruses are thought to be important environmental elements that contribute to the …

Immune checkpoint inhibitor related myasthenia gravis: single center experience and systematic review of the literature

H Safa, DH Johnson, VA Trinh, TE Rodgers… - … for immunotherapy of …, 2019 - Springer
Background Myasthenia gravis (MG) is a rare but life-threatening adverse event of immune
checkpoint inhibitors (ICI). Given the limited evidence, data from a large cohort of patients is …

Safety and efficacy of zilucoplan in patients with generalised myasthenia gravis (RAISE): a randomised, double-blind, placebo-controlled, phase 3 study

JF Howard, S Bresch, A Genge… - The Lancet …, 2023 - thelancet.com
Background Generalised myasthenia gravis is a chronic, unpredictable, and debilitating rare
disease, often accompanied by high treatment burden and with an unmet need for more …

Terminal complement inhibitor ravulizumab in generalized myasthenia gravis

T Vu, A Meisel, R Mantegazza, D Annane… - NEJM …, 2022 - evidence.nejm.org
Background Generalized myasthenia gravis (gMG) is a rare, chronic, and debilitating
autoimmune disease. Activation of the complement system by autoantibodies against the …

Immune checkpoint inhibitor–induced myocarditis with myositis/myasthenia gravis overlap syndrome: a systematic review of cases

R Pathak, A Katel, E Massarelli, VM Villaflor… - The …, 2021 - academic.oup.com
Background The development of immune checkpoint inhibitors (ICIs) represents a paradigm
shift in the treatment of cancers. Despite showing remarkable efficacy, these agents can be …

Advances and ongoing research in the treatment of autoimmune neuromuscular junction disorders

JJGM Verschuuren, J Palace, H Murai… - The Lancet …, 2022 - thelancet.com
Summary Myasthenia gravis and Lambert-Eaton myasthenic syndrome are antibody-
mediated autoimmune diseases of the neuromuscular junction that usually present with …

Immunotherapy in myasthenia gravis in the era of biologics

MC Dalakas - Nature Reviews Neurology, 2019 - nature.com
No consensus has been reached on the ideal therapeutic algorithm for myasthenia gravis
(MG). Most patients with MG require induction therapy with high doses of corticosteroids and …

Myasthenic crisis demanding mechanical ventilation: a multicenter analysis of 250 cases

B Neumann, K Angstwurm, P Mergenthaler, S Kohler… - Neurology, 2020 - AAN Enterprises
Objective To determine demographic characteristics, clinical features, treatment regimens,
and outcome of myasthenic crisis (MC) requiring mechanical ventilation (MV). Methods …

Understanding the burden of refractory myasthenia gravis

C Schneider-Gold, T Hagenacker… - Therapeutic …, 2019 - journals.sagepub.com
Myasthenia gravis (MG) is an autoantibody-mediated disease that compromises the
acetylcholine receptors or associated structures of the postsynaptic membrane of the …

Advances and challenges in the treatment of myasthenia gravis

C Schneider-Gold, NE Gilhus - Therapeutic advances in …, 2021 - journals.sagepub.com
Myasthenia gravis (MG) is a chronic autoimmune disease with fluctuating muscle weakness
and fatigability. Standard immunomodulatory treatment may fail to achieve sufficient …