Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals.
The disease was initially described in the 16th century and was the first animal pathogen …

The Picornaviridae represent a large family of small plus-strand RNA viruses that cause a
bewildering array of important human and animal diseases. Morphogenesis is the least …

Current understanding of the molecular basis of pathogenesis of foot-and-mouth disease
(FMD) has been achieved through over 100 years of study into the biology of the etiologic …

The mechanisms and factors involved in the replication of positive stranded RNA viruses are
still unclear. Using poliovirus as a model, we show that a long-range interaction between …

Replication of positive strand flaviviruses is mediated by the viral RNA-dependent RNA
polymerases (RdRP). To study replication of dengue virus (DEN), a flavivirus family member …

Publisher Summary It is clear from the experimental data that there are some similarities in
RNA replication for all eukaryotic positive-stranded RNA viruses—that is, the mechanism of …

RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that
is induced by double-stranded RNA. RNAi holds great promise as a novel nucleic acid …

A cloverleaf structure at the 5′ terminus of poliovirus RNA binds viral and cellular proteins.
To examine the role of the cloverleaf in poliovirus replication, we determined how cloverleaf …

The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a
complementary minus strand. This process is initiated by the covalent attachment of UMP to …

The cellular tropisms of eukaryotic viruses are shaped by their need for entry receptors and
intracellular transcription factors. Here we show that viral tropisms can also be regulated by …