LNCcation: lncRNA localization and function
MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …
phenomenon that influences numerous cellular processes. This is also evident for the large …
Therapeutic targeting of long non-coding RNAs in cancer
Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …
Xist RNA in action: Past, present, and future
A Loda, E Heard - PLoS genetics, 2019 - journals.plos.org
In mammals, dosage compensation of sex chromosomal genes between females (XX) and
males (XY) is achieved through X-chromosome inactivation (XCI). The X-linked X-inactive …
males (XY) is achieved through X-chromosome inactivation (XCI). The X-linked X-inactive …
Hacking the cancer genome: profiling therapeutically actionable long non-coding RNAs using CRISPR-Cas9 screening
Long non-coding RNAs (lncRNAs) represent a huge reservoir of potential cancer targets.
Such" onco-lncRNAs" have resisted traditional RNAi methods, but CRISPR-Cas9 genome …
Such" onco-lncRNAs" have resisted traditional RNAi methods, but CRISPR-Cas9 genome …
Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications
L Zhang, X Meng, X Zhu, D Yang, R Chen, Y Jiang… - Molecular cancer, 2019 - Springer
There is growing evidence that regions of the genome that cannot encode proteins play an
important role in diseases. These regions are usually transcribed into long non-coding …
important role in diseases. These regions are usually transcribed into long non-coding …
Linear and circular PVT1 in hematological malignancies and immune response: two faces of the same coin
Non coding RNAs (ncRNAs) have emerged as regulators of human carcinogenesis by
affecting the expression of key tumor suppressor genes and oncogenes. They are divided …
affecting the expression of key tumor suppressor genes and oncogenes. They are divided …
The crucial role of AR-V7 in enzalutamide-resistance of castration-resistant prostate cancer
Z Zheng, J Li, Y Liu, Z Shi, Z Xuan, K Yang, C Xu, Y Bai… - Cancers, 2022 - mdpi.com
Simple Summary Androgen receptor splice variant 7 (AR-V7) has always been considered a
key driver for triggering enzalutamide resistance of castration-resistant prostate cancer …
key driver for triggering enzalutamide resistance of castration-resistant prostate cancer …
Role of non‑coding RNA in pancreatic cancer
Y Lv, S Huang - Oncology letters, 2019 - spandidos-publications.com
Pancreatic cancer is a malignant disease that develops rapidly and carries a poor
prognosis. Currently, surgery is the only radical treatment. Non‑coding RNAs (ncRNAs) are …
prognosis. Currently, surgery is the only radical treatment. Non‑coding RNAs (ncRNAs) are …
Development of siRNA-loaded lipid nanoparticles targeting long non-coding RNA LINC01257 as a novel and safe therapeutic approach for t (8; 21) pediatric acute …
P Connerty, E Moles, CE de Bock, N Jayatilleke… - Pharmaceutics, 2021 - mdpi.com
Standard of care therapies for children with acute myeloid leukemia (AML) cause potent off-
target toxicity to healthy cells, highlighting the need to develop new therapeutic approaches …
target toxicity to healthy cells, highlighting the need to develop new therapeutic approaches …
Long noncoding RNAs in acute myeloid leukemia: functional characterization and clinical relevance
M Gourvest, P Brousset, M Bousquet - Cancers, 2019 - mdpi.com
Acute Myeloid Leukemia (AML) is the most common form of leukemia in adults with an
incidence of 4.3 per 100,000 cases per year. Historically, the identification of genetic …
incidence of 4.3 per 100,000 cases per year. Historically, the identification of genetic …