The difference between the estimated brain age and the chronological age ('brain-PAD')
could become a clinical biomarker. However, most brain age models were developed for …

Chronic musculoskeletal pain is a health burden that may accelerate the aging process.
Accelerated brain aging and epigenetic aging have separately been observed in those with …

Persistent fatigue is often reported in those with chronic musculoskeletal pain. Separately,
both chronic pain and chronic fatigue contribute to physical and cognitive decline in older …

Introduction Chronic pain is one of the leading causes of disability that may accelerate
biological aging and reduce physical function. Epigenetic clocks provide an estimate of how …

Purpose Knee OA-related pain varies in impact across individuals and may relate to central
nervous system alterations like accelerated brain aging processes. We previously reported …

Chronic pain is driven by factors across the biopsychosocial spectrum. Previously, we
demonstrated that magnetic resonance images (MRI)-based brain-predicted age differences …

The predicted brain age minus the chronological age ('brain-PAD') could become a clinical
biomarker. However, most brain age methods were developed to use research-grade high …