When considering all possible aging interventions evaluated to date, it is clear that calorie
restriction (CR) remains the most robust. Studies in numerous species have demonstrated …

Over a dozen advanced glycation end-products (AGEs) have been identified in tissue
proteins by chemical or immunological methods. Of these, about half are known to …

Dietary restriction (reduced calorie intake with nutritional maintenance) can extend lifespan
and may increase the resistance of the nervous system to age-related diseases including …

Background & aims Studies suggest that fasting before or during chemotherapy may induce
differential stress resistance, reducing the adverse effects of chemotherapy and enhancing …

Caloric restriction (CR) reduces the incidence and progression of spontaneous and induced
tumors in laboratory rodents while increasing mean and maximum life spans. It has been …

Caloric restriction is a potent experimental manipulation that extends mean and maximum
life span and delays the onset and progression of tumors in laboratory rodents. While caloric …

Life expectancy in the United States and other developed nations has increased remarkably
over the past century, and continues to increase. However, lifespan has remained relatively …

Background and objectives: The great similarity of the genomes of humans and other
species stimulated us to search for genes regulated by elements associated with human …

Progress in the control and treatment of pain may be facilitated by a better understanding of
mechanisms underlying nociceptive processing. Here we show that mice subjected to an …

To provide an improved understanding of the molecular basis of the aging process, it is
necessary to measure biological age on a tissue-specific basis. The role of DNA damage …