This review is an attempt to retrace the chronicle that starts from the discovery of the role of
nickel as the essential metal ion in urease for the enzymatic catalysis of urea, a key step in …

Urease is a nickel-dependent metalloenzyme found in plants, some bacteria, and fungi.
Bacterial enzyme is of special importance since it has been demonstrated as a potent …

The search for new compounds with a given biological activity requires enormous effort in
terms of manpower and cost. This effort arises from the large number of compounds that …

This review describes the functions, structures, and mechanisms of nine nickel-containing
enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase,[NiFe] …

The importance of nickel enzymes, where nickel serves as an essential cofactor, in Archaea,
bacteria, plants, and primitive eukaryotes, is well documented. 1 Despite the fact that no …

Background: Urease catalyzes the hydrolysis of urea, the final step of organic nitrogen
mineralization, using a bimetallic nickel centre. The role of the active site metal ions and …

Nickel is an essential nutrient for selected microorganisms where it participates in a variety
of cellular processes. Many microbes are capable of sensing cellular nickel ion …

Urease, a nickel-dependent metalloenzyme, is synthesized by plants, some bacteria, and
fungi. It catalyzes the hydrolysis of urea into ammonia and carbon dioxide. Although the …

▪ Abstract The protein sequence and structure databases are now sufficiently representative
that strategies nature uses to evolve new catalytic functions can be identified. Groups of …

Phytopathogenic fungi secrete chitin deacetylase (CDA) to escape the host's immunological
defense during infection. Here, we showed that the deacetylation activity of CDA toward …