The effects of aging in the hippocampus and cognitive decline
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …
social impairments. One structure of particular interest when considering aging and …
Regulation and function of adult neurogenesis: from genes to cognition
Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …
and potential impact on cognition but also to its localized vertical integration of different …
Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders
Extracellular vesicles (EVs) released by neural cells play an essential role in brain
homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse …
homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse …
[HTML][HTML] Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus
JM Encinas, TV Michurina, N Peunova, JH Park… - Cell stem cell, 2011 - cell.com
Production of new neurons in the adult hippocampus decreases with age; this decline may
underlie age-related cognitive impairment. Here we show that continuous depletion of the …
underlie age-related cognitive impairment. Here we show that continuous depletion of the …
[HTML][HTML] Role of Wnt signaling in adult hippocampal neurogenesis in health and disease
SB Arredondo, D Valenzuela-Bezanilla… - Frontiers in Cell and …, 2020 - frontiersin.org
Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals
provided by the local hippocampal microenvironment support neural stem cell proliferation …
provided by the local hippocampal microenvironment support neural stem cell proliferation …
[HTML][HTML] Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging
New neurons are generated in the adult hippocampus throughout life by neural
stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to external …
stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to external …
[HTML][HTML] Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus
Neural stem cells (NSCs) in the adult hippocampus divide infrequently, and the molecules
that modulate their quiescence are largely unknown. Here, we show that bone …
that modulate their quiescence are largely unknown. Here, we show that bone …
Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties
Grafting of neural stem cells (NSCs) derived from human induced pluripotent stem cells
(hiPSCs) has shown promise for brain repair after injury or disease, but safety issues have …
(hiPSCs) has shown promise for brain repair after injury or disease, but safety issues have …
When neurogenesis encounters aging and disease
In this review, we consider the evidence that a reduction in neurogenesis underlies aging-
related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD) …
related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD) …
Born this way: Hippocampal neurogenesis across the lifespan
The capability of the mammalian brain to generate new neurons through the lifespan has
gained much attention for the promise of new therapeutic possibilities especially for the …
gained much attention for the promise of new therapeutic possibilities especially for the …