Mesenchymal cells in the lung are crucial during development, but also contribute to the
pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most …

The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
that causes coronavirus disease 2019 (COVID-19) has led to 47 m infected cases and 1. 2 m …

Background Progressive fibrosing interstitial lung disease (ILD) is characterised by
parenchymal scar formation, leading to high morbidity and mortality. The ability to predict …

Autophagy, apoptosis, and the unfolded protein response (UPR) are fundamental biological
processes essential for manifold cellular functions in health and disease. Idiopathic …

Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease characterized by
myofibroblast accumulation and progressive lung scarring. To identify transcriptional gene …

Fibroblast activation including proliferation, survival, and ECM production is central to
initiation and maintenance of fibrotic lesions in idiopathic pulmonary fibrosis (IPF). However …

Pulmonary fibrosis (PF) is known as a chronic and irreversible disease characterized by
excessive extracellular matrix accumulation and lung architecture changes. Large efforts …

The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective
treatment. Given that the lung is exposed to the external environment, it is likely that …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown etiology with limited
treatment options. The role of the immune system in IPF has received increasing attention …

Idiopathic pulmonary fibrosis (IPF) is marked by the activation of fibroblasts, leading to
excessive production and deposition of extracellular matrix (ECM) within the lung …