Over the past decade, ocular imaging strategies have greatly advanced the diagnosis and
follow-up of patients with optic neuropathies. Developments in optic nerve imaging have …

This review summarizes the existing information on the concentration of H+(pH) in
vertebrate retinae and its changes due to various reasons. Special features of H+ …

Purpose: Despite the centrality of the retinal pigment epithelium (RPE) in vision and
retinopathy our picture of RPE morphology is incomplete. With a volumetric reconstruction of …

Delayed dark adaptation due to impaired rod photoreceptor homeostasis has been reported
as the earliest symptom of eye diseases such as age-related macular degeneration, diabetic …

Purpose: To test the hypothesis that changing energy needs alter mitochondria distribution
within the rod inner segment ellipsoid. Methods: In mice with relatively smaller (C57BL/6J …

Purpose: In Alzheimer's disease, central brain neurons show evidence for early
hyperactivity. It is unclear if this occurs in the retina, another disease target. Here, we tested …

Intrinsic optical signal (IOS) imaging of the retina, also termed as optoretinogram or
optoretinography (ORG), promises a non-invasive method for the objective assessment of …

Purpose: To test the hypothesis that rod energy biomarkers in light and dark are similar in
mice without functional rod transducin (Gnat1 rd17). Methods: Gnat1 rd17 and wildtype (WT) …

Purpose: The purpose of this study was to test the hypothesis that optical coherence
tomography (OCT) bioenergy-linked and anatomical biomarkers are responsive to an …

Here, we test whether early visual and OCT rod energy-linked biomarkers indicating
pathophysiology in nicotinamide nucleotide transhydrogenase (Nnt)-null 5xFAD mice also …