Estrogen signaling pathways, because of their central role in regulating the growth and
survival of breast tumor cells, have been identified as suitable and efficient targets for cancer …

Estrogen receptors (α and ß) are members of the steroid/thyroid nuclear receptors
superfamily of ligand-dependent transcription factors. Impact of the? isoform of estrogen …

Breast cancer is the most common malignancy in women around the world. Estrogen
receptor α (ERα) is expressed in approximately 70% of breast tumors, and considered as …

The estrogen receptor-α (ERα) is a transcription factor that regulates gene expression
through the binding to its cognate hormone 17β-estradiol (E2). ERα transcriptional activity is …

One subclass of antiestrogens, the selective estrogen receptor down-regulators (SERDs),
have received considerable attention of late as they competitively inhibit estrogen binding …

Genistein and apigenin are phytoestrogens present in commercial preparations used for the
treatment of postmenopausal symptoms. In this study, we assessed the influence of these …

Glyphosate, the active ingredient in several broad-spectrum herbicide formulations, has
been validated and widely used throughout the world. Recent reports have questioned its …

Cellular levels of estrogen receptor-α (ERα) protein are regulated primarily by the ubiquitin-
proteasome pathway. Dynamic interactions between ERα and the protein degradation …

Much research effort has been directed toward understanding how estrogen [17β-estradiol
(E2)] regulates cell proliferation and motility through the rapid, direct activation of …

Myotubular myopathy (MTM) is a severe X-linked disease without existing therapies. Here,
we show that tamoxifen ameliorates MTM-related histopathological and functional …