Epithelial ovarian cancer (EOC) is one of the cancers most influenced by hereditary factors.
A fourth to a fifth of unselected EOC patients carry pathogenic variants (PVs) in a number of …

The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …

Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using
data from large endometriosis and EOC genome-wide association meta-analyses, we …

The burden of human disease lies predominantly in polygenic diseases. Since the early
2000s, genome-wide association studies (GWAS) have identified genetic variants and loci …

Background Known risk alleles for epithelial ovarian cancer (EOC) account for
approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been …

Simple Summary Ovarian cancer is the leading cause of death by a gynecological tumor,
mainly due to its common detection in advanced stages and to its high resistance to …

To identify credible causal risk variants (CCVs) associated with different histotypes of
epithelial ovarian cancer (EOC), we performed genome-wide association analysis for …

Background Epigenomic dysregulation has been linked to solid tumour malignancies,
including ovarian cancers. Profiling of re-programmed enhancer locations associated with …

Currently, the detection of the allele asymmetry of gene expression from RNA-seq data or
the transcription factor binding from ChIP-seq data is one of the approaches used to identify …

Background Epithelial ovarian cancer (EOC) is the main subtype of ovarian cancer and
shows an aggressive phenotype and poor prognosis. Neuronal pentraxin II (NPTX2) is a …