In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow
pathway actively regulate conventional outflow resistance was proposed in the 1990s and …

Osteoporosis is a systemic disease that results in loss of bone density and increased
fracture risk, particularly in the vertebrae and the hip. This condition and associated …

Curcumin treatment was reported to delay the progression of OA, but its underlying
mechanism remains unclear. In this study, we aimed to investigate the molecular …

Biomineralization had apparently evolved independently in different phyla, using distinct
minerals, organic scaffolds, and gene regulatory networks (GRNs). However, diverse …

Rho-associated coiled-coil-containing kinases (ROCKs), serine/threonine protein kinases,
were initially identified as downstream targets of the small GTP-binding protein Rho …

Background The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity
must be appropriately controlled for proper bone remodeling, which is associated with …

Background Craniofacial skeletal deformities can be addressed by applying tensile force to
sutures to prompt sutural bone formation. The intricate process of mechanical modulation in …

It is well understood that the balance of bone formation and resorption is dependent on both
mechanical and biochemical factors. In addition to cell-secreted cytokines and growth …

One of the main concerns regarding nanomaterials is the cytotoxicity caused by engineered
nanoparticles (NPs) after inhalation, oral or dermal routes of exposure, intravenous …

MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that represent important
posttranscriptional regulators of protein-encoding genes. In particular, miRNAs play key …