Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

Ever since initial suggestions that instability at common fragile sites (CFSs) could be
responsible for chromosome rearrangements in cancers, CFSs and associated genes have …

There remains an unmet need for preclinical models to enable personalized therapy for
ovarian cancer (OC) patients. Here we evaluate the capacity of patient-derived organoids …

Chromosomal fragile sites are specific loci that preferentially exhibit gaps and breaks on
metaphase chromosomes following partial inhibition of DNA synthesis. Their discovery has …

Plasma levels of HDL cholesterol (HDL-C) have a strong inherited basis with heritability
estimates of 40-60%. The well-established inverse relationship between plasma HDL-C …

Osteosarcoma is an aggressive cancer in skeletal system with unknown molecular
mechanisms of etiology and pathogenesis, therefore it remains a challenge for current …

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-
associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl …

Head and neck squamous cell carcinoma (HNSCC) is a prevalent disease worldwide, and
the survival of HNSCC has not improved significantly over the last few decades. MicroRNAs …

Common fragile sites (CFSs) are regions of the genome prone to breakage by replication
inhibitors (extrinsic replication stress). Recently, we and others observed that oncogene …

[Frontiers in Bioscience 17, 331-348, January 1, 2012] 331 WW domain-containing proteins:
Retrospectives and the future Zaidoun Page 1 [Frontiers in Bioscience 17, 331-348, January …