Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

The role of oxidative stress in the physiopathology of human pregnancy is of particular
interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a …

BACKGROUND In humans, inadequate trophoblast invasion into the decidua is associated
with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction …

Pre-eclampsia is a pregnancy-specific disorder that has a worldwide prevalence of 5-8%. It
is one of the main causes of maternal and perinatal morbidity and mortality globally and …

Oxygen levels in the placental microenvironment throughout gestation are not constant, with
severe hypoxic conditions present during the first trimester. This hypoxic phase overlaps …

The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

Maternal uterine artery blood flow is critical to maintaining the intrauterine environment,
permitting normal placental function, and supporting fetal growth. It has long been believed …

Maternal uteroplacental blood flow increases during pregnancy. Altered uteroplacental
blood flow is a core predictor of abnormal pregnancy. Normally, the uteroplacental arteries …

Uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and
for this purpose they are remodelled into highly dilated vessels by the action of invading …