Carbohydrate-active enzymes (CAZymes) in the gut microbiome

JF Wardman, RK Bains, P Rahfeld… - Nature Reviews …, 2022 - nature.com
The 1013–1014 microorganisms present in the human gut (collectively known as the human
gut microbiota) dedicate substantial percentages of their genomes to the degradation and …

IgG glycosylation analysis

C Huhn, MHJ Selman, LR Ruhaak, AM Deelder… - …, 2009 - Wiley Online Library
A multitude of monoclonal IgG antibodies directed against a variety of therapeutic targets is
currently being developed and produced by biotechnological companies. The biological …

A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

ME Ackerman, B Moldt, RT Wyatt, AS Dugast… - Journal of …, 2011 - Elsevier
Phagocytosis can be induced via the engagement of Fcγ receptors by antibody-opsonized
material. Furthermore, the efficiency of antibody-induced effector functions has been shown …

Impact of immune complex size and glycosylation on IgG binding to human FcγRs

A Lux, X Yu, CN Scanlan… - The Journal of …, 2013 - journals.aai.org
IgG molecules are widely used as therapeutic agents either in the form of intact Abs or as Fc
fusion proteins. Although efficient binding of the IgG Fc fragment to cellular FcγRs may be …

Enzymes in the synthesis of glycoconjugates

RM Schmaltz, SR Hanson, CH Wong - Chemical reviews, 2011 - ACS Publications
Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …

An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) …

G Ferrari, J Pollara, D Kozink, T Harms… - Journal of …, 2011 - Am Soc Microbiol
Among nonneutralizing HIV-1 envelope antibodies (Abs), those capable of mediating
antibody-dependent cellular cytotoxicity (ADCC) activity have been postulated to be …

Control of cytokine production by human fc gamma receptors: implications for pathogen defense and autoimmunity

LTC Vogelpoel, DLP Baeten, EC de Jong… - Frontiers in …, 2015 - frontiersin.org
Control of cytokine production by immune cells is pivotal for counteracting infections via
orchestration of local and systemic inflammation. Although their contribution has long been …

Pathogen-driven degradation of endogenous and therapeutic antibodies during streptococcal infections

AG Toledo, E Bratanis, E Velásquez… - Nature …, 2023 - nature.com
Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and
systemic infections in humans. The molecular mechanisms that contribute to disease …

FcγRs in health and disease

F Nimmerjahn, JV Ravetch - Negative Co-Receptors and Ligands, 2011 - Springer
Genetic defects affecting the humoral immune response and especially the production of
antibodies of the immunoglobulin G (IgG) isotype result in a heightened susceptibility to …

Endo-β-N-acetylglucosaminidases from infant gut-associated bifidobacteria release complex N-glycans from human milk glycoproteins

D Garrido, C Nwosu, S Ruiz-Moyano… - Molecular & Cellular …, 2012 - ASBMB
Breastfeeding is one of the main factors guiding the composition of the infant gut microbiota
in the first months of life. This process is shaped in part by the high amounts of human milk …