The anterior cingulate cortex (ACC) is activated in both acute and chronic pain. In this
Review, we discuss increasing evidence from rodent studies that ACC activation contributes …

The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

Memory resides in engram cells distributed across the brain. However, the site-specific
substrate within these engram cells remains theoretical, even though it is generally accepted …

Social deficit is a core clinical feature of autism spectrum disorder (ASD) but the underlying
neural mechanisms remain largely unclear. We demonstrate that structural and functional …

Spinal sensory transmission is under descending biphasic modulation, and descending
facilitation is believed to contribute to chronic pain. Descending modulation from the …

Pain associates both sensory and emotional aversive components, and often leads to
anxiety and depression when it becomes chronic. Here, we characterized, in a mouse …

Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

Pain is a complex experience including sensory-discriminative and emotional-affective
components. Base on the intensity and chronification of pain, pain is divided into …

Neuropathic pain is a debilitating chronic pain condition occurring after damage in the
nervous system and is refractory to the currently available treatments. Major challenges …

Effective treatments for chronic pain remain limited. Conceptually, a closed-loop neural
interface combining sensory signal detection with therapeutic delivery could produce timely …