MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …

Only natural selection can account for the extreme genetic diversity of genes of the major
histocompatibility complex (MHC). Although the structure and function of classic MHC genes …

Background Transplantation of hematopoietic cells from unrelated donors can cure blood
disorders but carries a significant risk of acute graft-versus-host disease (GVHD). The risk is …

The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the
absence of major istocompatibility complex class II (MHCII) expression. Considering the …

▪ Abstract Precise regulation of major histocompatibility complex class II (MHC-II) gene
expression plays a crucial role in the control of the immune response. A major breakthrough …

Recombinant murine interleukin (IL)-12 (rmIL-12) exhibits antitumor, antiviral, and
antimicrobial activities and can modify allergic inflammatory reactions in animal models …

Abnormal expression of major histocompatibility complex (MHC) class I and class II in
various tissues is associated with autoimmune disease. Autoimmune responses can be …

MHC class II (MHCII) molecules play a pivotal role in the induction and regulation of immune
responses. The transcriptional coactivator class II transactivator (CIITA) controls MHCII …

Toll-like receptors (TLRs) initiate an innate immune response. TLR3 on dendritic cells
recognize double-stranded (ds) RNA and then signal increases in cytokines and recognition …

CUTA, a gene that can complement a transcriptional mutation of the major histocompatibiiity
complex (MHC) class Ii genes, was tested for its ability to function as a coactivator. CflTA …