Statistics or biology: the zero-inflation controversy about scRNA-seq data
Researchers view vast zeros in single-cell RNA-seq data differently: some regard zeros as
biological signals representing no or low gene expression, while others regard zeros as …
biological signals representing no or low gene expression, while others regard zeros as …
On the dependency of cellular protein levels on mRNA abundance
The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …
importance for basic and translational life science research and has been studied by …
Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes
Y Zhang, V Bharathi, T Dokoshi… - Proceedings of the …, 2024 - National Acad Sciences
It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
leads to the strong but ineffective inflammatory response that characterizes severe …
leads to the strong but ineffective inflammatory response that characterizes severe …
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
Single-cell transcriptomics reveals gene expression heterogeneity but suffers from
stochastic dropout and characteristic bimodal expression distributions in which expression is …
stochastic dropout and characteristic bimodal expression distributions in which expression is …
Enhancer control of transcriptional bursting
Transcription is episodic, consisting of a series of discontinuous bursts. Using live-imaging
methods and quantitative analysis, we examine transcriptional bursting in living Drosophila …
methods and quantitative analysis, we examine transcriptional bursting in living Drosophila …
Causes and consequences of hematopoietic stem cell heterogeneity
Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs).
Classically, stem and progenitor populations have been considered discrete homogeneous …
Classically, stem and progenitor populations have been considered discrete homogeneous …
Comparative analysis of droplet-based ultra-high-throughput single-cell RNA-seq systems
Since its establishment in 2009, single-cell RNA sequencing (RNA-seq) has been a major
driver behind progress in biomedical research. In developmental biology and stem cell …
driver behind progress in biomedical research. In developmental biology and stem cell …
Single-cell RNA-seq: advances and future challenges
AE Saliba, AJ Westermann, SA Gorski… - Nucleic acids …, 2014 - academic.oup.com
Phenotypically identical cells can dramatically vary with respect to behavior during their
lifespan and this variation is reflected in their molecular composition such as the …
lifespan and this variation is reflected in their molecular composition such as the …
Spatially resolved, highly multiplexed RNA profiling in single cells
INTRODUCTION The copy number and intracellular localization of RNA are important
regulators of gene expression. Measurement of these properties at the transcriptome scale …
regulators of gene expression. Measurement of these properties at the transcriptome scale …