Mammalian cytochromes P450 are an important class of enzymes involved in the biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …
SC Lee, BC Bennett, WX Hong, Y Fu… - Proceedings of the …, 2013 - National Acad Sciences
Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We have developed a family of steroid-based facial amphiphiles (FAs) that are structurally …
Abstract Cytochrome P450 (CYP) family 1, 2, and 3 enzymes play an essential role in the metabolic clearance and detoxification of a myriad of structurally and chemically diverse …
EF Johnson, CD Stout - Journal of Biological Chemistry, 2013 - ASBMB
X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These …
Cytochrome P450 (CYP) epoxygenases are a special subset of heme-containing CYP enzymes capable of performing the epoxidation of polyunsaturated fatty acids (PUFA) and …
Cytochrome P450 enzymes are renowned for their ability to insert oxygen into an enormous variety of compounds with a high degree of chemo-and regio-selectivity under mild …
F Zhang, T Zeng, R Wu - Journal of Chemical Information and …, 2023 - ACS Publications
Natural products and their derivatives are widely used across various industries, particularly pharmaceuticals. Modern engineered biosynthesis provides an alternative way of producing …
The superfamily of cytochrome P450s forms a large class of heme monooxygenases with more than 13,000 enzymes represented in organisms from all biological kingdoms. Despite …
G Chen, M Fan, Y Liu, B Sun, M Liu, J Wu, N Li… - Frontiers in …, 2019 - frontiersin.org
The non-covalent interactions between small drug molecules and disease-related proteins (ligand-target interactions) mediate various pharmacological processes in the treatment of …