As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still
thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the …

NMDA-type glutamate receptors (NMDARs) mediate many forms of synaptic plasticity. These
tetrameric receptors consist of two obligatory NR1 subunits and two regulatory subunits …

Synaptic plasticity is considered essential for learning and storage of new memories.
Whether all synapses on a given neuron have the same ability to express long-term …

Long-term synaptic plasticity is a major cellular substrate for learning, memory, and
behavioral adaptation. Although early examples of long-term synaptic plasticity described a …

Gq-coupled, M1 muscarinic acetylcholine receptors (mAChRs) facilitate hippocampal
learning, memory, and synaptic plasticity. M1 mAChRs induce long-term synaptic …

Resolving how our brains encode information requires an understanding of the cellular
processes taking place during memory formation. Since the 1970s, considerable effort has …

GABAergic inhibition plays a central role in the control of pyramidal cell ensemble activities;
thus, any signaling mechanism that regulates inhibition is able to fine-tune network patterns …

Adequate pain sensitivity requires a delicate balance between excitation and inhibition in
the dorsal horn of the spinal cord. This balance is severely impaired in neuropathy leading …

Glial cells play an essential role in the complex function of the nervous system. In particular,
astrocytes provide nutritive support for neuronal cells and are involved in regulating synaptic …

Sensory stimulation conveys spike discharges of variable frequency and duration along the
mossy fibres of cerebellum raising the question of whether and how these patterns …