Early life microbial exposures and allergy risks: opportunities for prevention

H Renz, C Skevaki - Nature Reviews Immunology, 2021 - nature.com
Allergies, including asthma, food allergy and atopic dermatitis, are increasing in prevalence,
particularly in westernized countries. Although a detailed mechanistic explanation for this …

Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma

W Luo, J Hu, W Xu, J Dong - Frontiers in Immunology, 2022 - frontiersin.org
Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …

Epithelial cell dysfunction, a major driver of asthma development

IH Heijink, VNS Kuchibhotla, MP Roffel, T Maes… - Allergy, 2020 - Wiley Online Library
Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

Role of viral infections in the development and exacerbation of asthma in children

T Jartti, JE Gern - Journal of Allergy and Clinical Immunology, 2017 - Elsevier
Viral infections are closely linked to wheezing illnesses in children of all ages. Respiratory
syncytial virus (RSV) is the main causative agent of bronchiolitis, whereas rhinovirus (RV) is …

The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development

SM Teo, D Mok, K Pham, M Kusel, M Serralha, N Troy… - Cell host & …, 2015 - cell.com
The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory
infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma …

Risk factors for asthma: is prevention possible?

R Beasley, A Semprini, EA Mitchell - The Lancet, 2015 - thelancet.com
Asthma is one of the most common diseases in the world, resulting in a substantial burden of
disease. Although rates of deaths due to asthma worldwide have reduced greatly over the …

The role of the microbiome in asthma: the gut–lung axis

F Frati, C Salvatori, C Incorvaia, A Bellucci… - International journal of …, 2018 - mdpi.com
Asthma is one of the most common chronic respiratory diseases worldwide. It affects all ages
but frequently begins in childhood. Initiation and exacerbations may depend on individual …

The role of respiratory syncytial virus‐and rhinovirus‐induced bronchiolitis in recurrent wheeze and asthma—a systematic review and meta‐analysis

H Makrinioti, K Hasegawa… - Pediatric Allergy and …, 2022 - Wiley Online Library
Introduction Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis.
RSV‐induced bronchiolitis has been associated with preschool wheeze and asthma in …

More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis

A Frey, LP Lunding, JC Ehlers, M Weckmann… - Frontiers in …, 2020 - frontiersin.org
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

[HTML][HTML] Rhinovirus infections and their roles in asthma: etiology and exacerbations

DJ Jackson, JE Gern - The Journal of Allergy and Clinical Immunology: In …, 2022 - Elsevier
Rhinovirus infections can cause wheezing illnesses in all age groups. In preschool children,
rhinovirus infections frequently initiate acute wheezing illnesses. Children who wheeze with …