Healthy functioning of the human brain relies on effective shielding of the sensitive neural
microenvironment from potentially disruptive xenobiotic agents circulating in the periphery …

Alzheimer's disease is a progressive neurodegenerative disorder characterised by the
gradual onset of dementia. The pathological hallmarks of the disease are β‐amyloid (Aβ) …

Alzheimer's disease (AD) is the most common form of dementia in the elderly and its
prevalence is set to increase rapidly in coming decades. However, there are as yet no …

It is now 100 years since the nosological definition of Alzheimer's disease emerged. In the
first 80 years, very little progress was made in understanding the mechanisms that caused …

Aβ is implicated in the initiation and progression of Alzheimer's disease (AD) by the
phenotypic analysis of mutations in three human genes that lead to inherited, early forms of …

A novel series of acetamide derivatives possessing both 2-imino-4-arylthiazoles and
morpholine or different piperazines were synthesized and characterized by IR, 1 H NMR, 13 …

Most gene mutations associated with Alzheimer's disease point to the metabolism of amyloid
precursor protein as potential cause. The β-and γ-secretases are two executioners of …

In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl) aminophenyl] thiazole derivatives and
2-[4-[2-substituted 4-methylthiazole-5-yl] thiazole-2-yl] amino-5-arylidenethiazoline-4-one …

(*) Notice: Subject to any disclaimer, the term of this W000-b.* liprevent).* patent is extended
or adjusted under 35 Vanes et al. in Nature 435 (16), pp. 959-963 (2005).* USC 154 (b) by …

Inhibition of γ-secretase, one of the enzymes responsible for the cleavage of the amyloid
precursor protein (APP) to produce pathogenic Aβ peptides, is an attractive approach for the …