Abstract T helper type 1 (Th1) lymphocytes secrete secrete interleukin (IL)-2, interferon-γ,
and lymphotoxin-α and stimulate type 1 immunity, which is characterized by intense …

Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of …

In the mid-1980s, Mosmann, Coffman, and their colleagues discovered that murine CD4+
helper T-cell clones could be distinguished by the cytokines they synthesized. The isolation …

Antigen‐and mitogen‐stimulated cytokine production by peripheral blood mononuclear cells
(PBMC) of 50 pregnant women and 31 age‐and sex‐matched non‐pregnant controls were …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Several chronic infections known to be associated with malignancy have established
oncogenic properties. However the existence of chronic inflammatory conditions that do not …

Homeostasis in the immune system depends on a balance between the responses that
control infection and tumour growth and the reciprocal responses that prevent inflammation …

AIDS, caused by the retroviruses human immunodeficiency virus type 1 and type 2 (HIV-1
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how …

Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid stem cell
origin that populate all lymphoid organs including the thymus, spleen, and lymph nodes, as …

Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …