Molecular changes in malignant tissue can lead to an increase in the expression levels of
various proteins or receptors that can be used to target the disease. In oncology, diagnostic …

Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs)
with symptoms ranging from flushing and breathing difficulties to hypothermia, hypotension …

Histologic transformation to small cell neuroendocrine prostate cancer occurs in a subset of
patients with advanced prostate cancer as a mechanism of treatment resistance …

Background Current measurements of multiple myeloma disease burden are suboptimal.
Daratumumab is a monoclonal antibody that targets CD38, an antigen expressed on nearly …

Systemic cytokine release and on-target/off-tumor toxicity to normal tissues are the main
adverse effects limiting the clinical utility of T cell–redirecting therapies. This study was …

In the past three decades, a great interest has arisen in the use of immunoglobulins as
therapeutic agents. In particular, since the approval of the first monoclonal antibody …

Antiangiogenic therapies have been demonstrated to improve the efficacy of immune
checkpoint inhibition by overcoming the immunosuppressive status of the tumor …

Objective: The goal is to evaluate avelumab, an anti-PD-L1 monoclonal immunoglobulin G
antibody labeled with zirconium-89 in human PD-L1-expressing cancer cells and mouse …

Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread
metastatic cancers. Most current approaches rely on the use of vectors to deliver …