MSCs are an extensively used cell type in clinical trials today. The initial rationale for their
clinical testing was based on their differentiation potential. However, the lack of correlation …

Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration
of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of …

Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

Protein oxidative modifications, also known as protein oxidation, are a major class of protein
posttranslational modifications. They are caused by reactions between protein amino acid …

Therapeutic strategies to protect the ischemic myocardium have been studied extensively.
Reperfusion is the definitive treatment for acute coronary syndromes, especially acute …

Reperfusion therapy must be applied as soon as possible to attenuate the ischemic insult of
acute myocardial infarction (AMI). However reperfusion is responsible for additional …

Acute myocardial infarction is associated with high rates of morbidity and mortality and can
cause irreversible myocardial damage. Timely reperfusion is critical to limit infarct size and …

Outcomes after cardiac arrest remain poor more than a half a century after closed chest
cardiopulmonary resuscitation (CPR) was first described. This review article is focused on …

We critically assess the proposal that succinate-fuelled reverse electron flow (REF) drives
mitochondrial matrix superoxide production from Complex I early in reperfusion, thus acting …