Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

DNA methylation, a key epigenetic driver of transcriptional silencing, is universally
dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as …

Summary S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) link one-
carbon metabolism to methylation status. However, it is unknown whether regulation of SAM …

The discovery of cancer dependencies has the potential to inform therapeutic strategies and
to identify putative drug targets. Integrating data from comprehensive genomic profiling of …

Tumor progression upon treatment arises from preexisting resistant cancer cells and/or
adaptation of persister cancer cells committing to an expansion phase. Here, we show that …

Epigenetic modifications on chromatin are most commonly thought to be involved in the
transcriptional regulation of gene expression. Due to their dependency on small-molecule …

As a master regulator of chromatin function, the lysine methyltransferase EZH2 orchestrates
transcriptional silencing of developmental gene networks. Overexpression of EZH2 is …

Despite the discovery of modified nucleic acids nearly 75 years ago, their biological
functions are still being elucidated. N 6‐methyladenosine (m6A) is the most abundant …

Abstract S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on
central nervous system function through cellular transmethylation pathways, including the …