Viruses must co-opt the cellular translation machinery to produce progeny virions.
Eukaryotic viruses have evolved a variety of ways to manipulate the cellular translation …

Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

Maternal infection and inflammation during pregnancy are associated with
neurodevelopmental disorders in offspring, but little is understood about the molecular …

We are just beginning to understand how translational control affects tumour initiation and
malignancy. Here we use an epidermis-specific, in vivo ribosome profiling strategy to …

Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions.
This can be achieved by the phosphorylation-mediated inactivation of a key translation …

Translation of cellular mRNAs via initiation at Internal Ribosome Entry Sites (IRESs) has
received increased attention during recent years due to its emerging significance for many …

Summary The PI3K/mTOR-pathway is the most commonly dysregulated pathway in
epithelial cancers and represents an important target for cancer therapeutics. Here, we show …

The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic
reticulum (ER) stress. In acute/transient ER stress, decreased global protein synthesis and …

Background eIF2α is a regulatory node that controls protein synthesis initiation by its
phosphorylation or dephosphorylation. General control nonderepressible-2 (GCN2), protein …

Increasing studies have revealed that a subset of circular RNAs (circRNAs) harbor an open
reading frame and can act as protein-coding templates to generate functional proteins that …