The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions
Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
[HTML][HTML] Endothelial dysfunction—a major mediator of diabetic vascular disease
CM Sena, AM Pereira, R Seiça - … et Biophysica Acta (BBA)-molecular basis …, 2013 - Elsevier
The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …
vascular tone and structure. Endothelial cells produce a wide range of factors that also …
[HTML][HTML] PARPs in lipid metabolism and related diseases
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
Poly (ADP-ribose) polymerase (PARP) and PARP inhibitors: mechanisms of action and role in cardiovascular disorders
RJ Henning, M Bourgeois, RD Harbison - Cardiovascular toxicology, 2018 - Springer
Poly (ADP-ribosyl) ation is an immediate cellular repair response to DNA damage and is
catalyzed primarily by poly (ADP-ribose) polymerase-1 (PARP1), which is the most …
catalyzed primarily by poly (ADP-ribose) polymerase-1 (PARP1), which is the most …
The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism
Abstract Poly (ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA
repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and …
repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and …
Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications
Cardiovascular diseases (CVDs) arise from a complex interplay among genomic, proteomic,
and metabolomic abnormalities. Emerging evidence has recently consolidated the presence …
and metabolomic abnormalities. Emerging evidence has recently consolidated the presence …
Necrotic cell death in atherosclerosis
W Martinet, DM Schrijvers, GRY De Meyer - Basic research in cardiology, 2011 - Springer
Necrosis is a type of cell death characterized by a gain in cell volume, swelling of
organelles, rupture of the plasma membrane and subsequent loss of intracellular contents …
organelles, rupture of the plasma membrane and subsequent loss of intracellular contents …
Poly (ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-κB upon TLR4 stimulation
The role of NF-κB in the expression of inflammatory genes and its participation in the overall
inflammatory process of chronic diseases and acute tissue injury are well established. We …
inflammatory process of chronic diseases and acute tissue injury are well established. We …
Endothelial dysfunction in the apolipoprotein E-deficient mouse: insights into the influence of diet, gender and aging
SS Meyrelles, VA Peotta, TMC Pereira… - Lipids in health and …, 2011 - Springer
Since the early 1990s, several strains of genetically modified mice have been developed as
models for experimental atherosclerosis. Among the available models, the apolipoprotein E …
models for experimental atherosclerosis. Among the available models, the apolipoprotein E …
Poly (ADP‐ribose) polymerase 1 (PARP1) in atherosclerosis: from molecular mechanisms to therapeutic implications
Poly (ADP‐ribosyl) ation reactions, carried out by poly (ADP‐ribose) polymerases
(PARPs/ARTDs), are reversible posttranslational modifications impacting on numerous …
(PARPs/ARTDs), are reversible posttranslational modifications impacting on numerous …