We posit the following hypothesis: Independently of whether malignant tumors are initiated
by a fundamental reprogramming of gene expression or seeded by stem cells,“waves” of …

Abstract γ-secretase, which assembles as a tetrameric complex, is an aspartyl protease that
proteolytically cleaves substrate proteins within their membrane-spanning domain; a …

The incidence of melanoma is increasing over the years with a still poor prognosis and the
lack of a cure able to guarantee an adequate survival of patients. Although the new immuno …

Background It was well known that the clinical use of chemotherapeutic drugs is restricted by
severe adverse reactions and drug resistances. Thus it is necessary to figure out a strategy …

Psoriasis, a chronic inflammatory skin disorder, is characterized by aberrant keratinocyte
proliferation and differentiation in the epidermis. Although the pathogenesis of psoriasis is …

Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and
resistance to currently used treatments. To overcome the limitations of the available …

Abstract Background miR-143 and miR-145 are believed to function as colon cancer tumor
suppressors, as they inhibit colon cancer cell growth and are downregulated in sporadic …

Objectives The co-occurrence of melanoma and Parkinson's disease (PD) is higher than
expected. We review the relationship between melanoma and PD, then proffer a hypothesis …

The present study aimed at investigating genetic variations, specific signal pathways, or
biological processes of chromosome 1 genes between subtypes and stages of lung cancer …

We explored the effect of baicalein on the ferroptosis of melanocytes in vitiligo. Melanocytes
were treated with single RSL3 or combined RSL3 with FAC for 24 h and the effect of …