Microarray technology allows the simultaneous analysis of thousands of parameters within a
single experiment. Microspots of capture molecules are immobilized in rows and columns …

▪ Abstract Antibodies are unique in their high affinity and specificity for a binding partner, a
quality that has made them one of the most useful molecules for biotechnology and …

The Fab portion of a humanized antibody (Fab-12; IgG form known as rhuMAb VEGF) to
vascular endothelial growth factor (VEGF) has been affinity-matured through …

The ability of antibodies to neutralize diverse primary isolates of human immunodeficiency
virus-type 1 in vitro has been questioned, with implications for the likely efficacy of vaccines …

We describe the investigation of methodologies for the creation of very high affinity human
antibodies. The high affinity human antibody b4/12 was optimized for its affinity to the human …

We determined the extent to which additional binding energy could be achieved by
diversifying the complementarity determining regions (CDRs) located in the center of the …

Antibodies have been used to prevent or treat viral infections since the nineteenth century,
but the full potential to use passive immunization for infectious diseases has yet to be …

Six recombinant human Fab fragments that were derived from the same human
immunodeficiency virus type 1 (HIV-1)-infected individual and are directed against the CD4 …

US7985840B2 - Synthetic antibody phage libraries - Google Patents US7985840B2 -
Synthetic antibody phage libraries - Google Patents Synthetic antibody phage libraries …

Phage antibody-display is rapidly maturing into a very effective tool for antibody generation.
The recent development of large primary antibody libraries enables selection of antibodies …