The role of STAT3 in autophagy
L You, Z Wang, H Li, J Shou, Z Jing, J Xie, X Sui… - Autophagy, 2015 - Taylor & Francis
Autophagy is an evolutionarily conserved process in eukaryotes that eliminates harmful
components and maintains cellular homeostasis in response to a series of extracellular …
components and maintains cellular homeostasis in response to a series of extracellular …
Interferon-γ: an overview of signals, mechanisms and functions
Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …
transcriptional regulation of immunologically relevant genes. This article reviews the current …
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
PC Heinrich, I Behrmann, S Haan… - Biochemical …, 2003 - portlandpress.com
The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM
(oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are …
(oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are …
Stats: transcriptional control and biological impact
DE Levy, JE Darnell Jr - Nature reviews Molecular cell biology, 2002 - nature.com
Extracellular proteins bound to cell-surface receptors can change nuclear gene expression
patterns in minutes, with far-reaching consequences for development, cell growth and …
patterns in minutes, with far-reaching consequences for development, cell growth and …
Biology and significance of the JAK/STAT signalling pathways
H Kiu, SE Nicholson - Growth factors, 2012 - Taylor & Francis
Since its discovery two decades ago, the activation of the Janus kinase/signal transducers
and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth …
and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth …
Regulation of JAK–STAT signalling in the immune system
K Shuai, B Liu - Nature Reviews Immunology, 2003 - nature.com
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) pathway has an important role in the control of immune responses. Dysregulation of …
(STAT) pathway has an important role in the control of immune responses. Dysregulation of …
Signaling through the JAK/STAT pathway, recent advances and future challenges
T Kisseleva, S Bhattacharya, J Braunstein… - Gene, 2002 - Elsevier
Investigation into the mechanism of cytokine signaling led to the discovery of the JAK/STAT
pathway. Following the binding of cytokines to their cognate receptor, signal transducers …
pathway. Following the binding of cytokines to their cognate receptor, signal transducers …
Cytokine signaling in 2002: new surprises in the Jak/Stat pathway
Abstract The importance of Jak-Stat pathway signaling in regulating cytokine-dependent
gene expression and cellular development/survival is well established. Nevertheless …
gene expression and cellular development/survival is well established. Nevertheless …
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi …
The host innate immune response is an important deterrent of severe viral infection in
humans and animals. Nuclear import factors function as key gatekeepers that regulate the …
humans and animals. Nuclear import factors function as key gatekeepers that regulate the …
Signal transduction and the control of gene expression
AH Brivanlou, JE Darnell Jr - Science, 2002 - science.org
More than 2000 transcription factors are encoded in the human genome. Such proteins have
often been classified according to common structural elements. But because transcription …
often been classified according to common structural elements. But because transcription …