Bee venom: an updating review of its bioactive molecules and its health applications

M Carpena, B Nuñez-Estevez, A Soria-Lopez… - Nutrients, 2020 - mdpi.com
Bee venom (BV) is usually associated with pain since, when humans are stung by bees,
local inflammation and even an allergic reaction can be produced. BV has been traditionally …

Updating Phospholipase A2 Biology

M Murakami, H Sato, Y Taketomi - Biomolecules, 2020 - mdpi.com
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …

Processing technologies for bee products: An overview of recent developments and perspectives

X Luo, Y Dong, C Gu, X Zhang, H Ma - Frontiers in Nutrition, 2021 - frontiersin.org
Increased demand for a more balanced, healthy, and safe diet has accelerated studies on
natural bee products (including honey, bee bread, bee collected pollen royal jelly, propolis …

Modulation of immunity by the secreted phospholipase A2 family

M Murakami, H Sato, Y Taketomi - Immunological reviews, 2023 - Wiley Online Library
Among the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2
hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 …

Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A2

M Mangini, R D'angelo, C Vinciguerra… - Frontiers in Cell and …, 2022 - frontiersin.org
Increasing evidence points to the involvement of group IIA secreted phospholipase A2
(sPLA2-IIA) in pathologies characterized by abnormal osteoclast bone-resorption activity …

Human Group IIA Phospholipase A2—Three Decades on from Its Discovery

KF Scott, TJ Mann, S Fatima, M Sajinovic, A Razdan… - Molecules, 2021 - mdpi.com
Phospholipase A2 (PLA2) enzymes were first recognized as an enzyme activity class in
1961. The secreted (sPLA2) enzymes were the first of the five major classes of human …

Interactions of small molecule inhibitors with secreted phospholipase A2: A review of the structural data

C Crous, A Petzer, JP Petzer - Chemical Biology & Drug Design, 2024 - Wiley Online Library
The secreted phospholipase A2 (sPLA2) family of enzymes hydrolyzes glycerophospholipid
substrates at the sn‐2 position of the acyl ester bond. Besides their roles in the degradation …

What do secreted phospholipases A2 have to offer in combat against different viruses up to SARS-CoV-2?

J Pungerčar, F Bihl, G Lambeau, I Križaj - Biochimie, 2021 - Elsevier
Secreted phospholipases A 2 (sPLA 2 s) form a widespread group of structurally-related
enzymes that catalyse the hydrolysis of the sn-2 ester bond of glycerophospholipids to …

Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model

M Dacheux, S Chaouch, A Joy, A Labat, C Payré… - Biochimie, 2021 - Elsevier
We previously showed that injection of recombinant human group IIA secreted
phospholipase A 2 (hGIIA sPLA 2) to Plasmodium chabaudi-infected mice lowers …

The Biotechnological Potential of Bee Venom

AD Rășinar, D Moraru, R Lazăr, S Pătruică - Scientific Papers Animal …, 2023 - spasb.ro
In many terrestrial ecosystems, the Apis mellifera species played an essential role, being
one of the most beneficial insects worldwide. Bee venom (BV) has the role of protecting the …