Multiomics studies investigating recurrent pregnancy loss: an effective tool for mechanism exploration

J Li, L Wang, J Ding, Y Cheng, L Diao, L Li… - Frontiers in …, 2022 - frontiersin.org
Patients with recurrent pregnancy loss (RPL) account for approximately 1%-5% of women
aiming to achieve childbirth. Although studies have shown that RPL is associated with …

The role of decidual subpopulations in implantation, menstruation and miscarriage

J Muter, CS Kong, JJ Brosens - Frontiers in reproductive health, 2021 - frontiersin.org
In each menstrual cycle, the endometrium becomes receptive to embryo implantation while
preparing for tissue breakdown and repair. Both pregnancy and menstruation are …

Energy metabolism and maternal-fetal tolerance working in decidualization

X Meng, C Chen, J Qian, L Cui, S Wang - Frontiers in Immunology, 2023 - frontiersin.org
One pivotal aspect of early pregnancy is decidualization. The decidualization process
includes two components: the differentiation of endometrial stromal cells to decidual stromal …

Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage

L Tang, XH Xu, S Xu, Z Liu, Q He, W Li, J Sun… - Cell Reports …, 2023 - cell.com
Recurrent spontaneous miscarriage (RSM) affects 1%–2% of fertile women worldwide and
poses a risk of future pregnancy complications. Increasing evidence has indicated that …

Gynecology meets big data in the disruptive innovation medical era: state-of-art and future prospects

R Khamisy-Farah, LB Furstenau, JD Kong… - International Journal of …, 2021 - mdpi.com
Tremendous scientific and technological achievements have been revolutionizing the
current medical era, changing the way in which physicians practice their profession and …

LC-MS analysis revealed the significantly different metabolic profiles in spent culture media of human embryos with distinct morphology, karyotype and implantation …

C Eldarov, A Gamisonia, V Chagovets… - International journal of …, 2022 - mdpi.com
In this study we evaluated possible differences in metabolomic profiles of spent embryo
culture media (SECM) of human embryos with distinct morphology, karyotype, and …

The proteomes of endometrial stromal cell-derived extracellular vesicles following a decidualizing stimulus define the cells' potential for decidualization success

S Gurung, DW Greening, A Rai, QH Poh… - Molecular human …, 2021 - academic.oup.com
Adequate endometrial stromal cell (ESC) decidualization is vital for endometrial health.
Given the importance of extracellular vesicles (EVs) in intercellular communication, we …

[HTML][HTML] Human Endometrial Pericytes: A Comprehensive Overview of Their Physiological Functions and Implications in Uterine Disorders

Y Tang, C Frisendahl, TT Piltonen, RK Arffman… - Cells, 2024 - mdpi.com
Pericytes are versatile cells integral to the blood vessel walls of the microcirculation, where
they exhibit specific stem cell traits. They are essential in modulating blood flow, ensuring …

Discovery and validation of peritoneal endometriosis biomarkers in peritoneal fluid and serum

SL Loy, J Zhou, L Cui, TY Tan, TX Ee… - Reproductive …, 2021 - Elsevier
Research question What are the potential biomarkers for peritoneal endometriosis in
peritoneal fluid and serum? Design Case-control studies composed of independent …

Acyl-CoA long-chain synthetase 1 (ACSL1) protects the endometrium from excess palmitic acid stress during decidualization

W Gu, B Zeng, Y Zhang, F Zhao, X Lin, X Wang, N Liu… - Cellular …, 2024 - Elsevier
Endometrial receptivity relies on the functional and morphological change of endometrium
stromal cells (EnSCs) and epithelial cells in the secretory phase. Decidualization of ESCs …