Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Cancer Stem Cells Cancers arise in tissues that can replicate and self-renew. Like normal
tissues, cancers can replenish themselves, grow, and metastasize because of stem cells that …

Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of
time. This state, which is reversible, has long been viewed as dormant and with minimal …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Satellite cells (SCs) are myogenic stem cells found in skeletal muscle that function to repair
tissue damaged by injury or disease. SCs are quiescent at rest, although the signaling …

Unlike mammals, zebrafish are able to regenerate a damaged retina. Key to this
regenerative response are Müller glia that respond to retinal injury by undergoing a …

Notch signaling plays a key role in virtually all tissues and organs in metazoans; however,
limited examples are available for the regulatory role of this pathway in adult quiescent stem …

The Notch pathway is often regarded as a developmental pathway, but components of Notch
signalling are expressed and active in the adult brain. With the advent of more sophisticated …

Major developments in the neural stem cell (NSC) field in recent years provide new insights
into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on …