Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory
syndrome and not an independent disease. HLH represents the extreme end of a severe …

Viral infections are serious battles between pathogens and hosts. They can result in cell
death, elimination of the virus or latent infection keeping both cells and pathogens alive. The …

The COPII coat produces ER-derived transport vesicles. Recent findings suggest that the
COPII coat is a highly dynamic polymer and that efficient capture of cargo molecules into …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, hyperinflammatory
syndrome, characterized by the uncontrolled activation of macrophages and T cells, eliciting …

The replication of rotavirus is a complex process that is orchestrated by an exquisite
interplay between the rotavirus non-structural and structural proteins. Subsequent to particle …

Hemophagocytic syndrome (HS) is a severe and often fatal syndrome resulting from potent
and uncontrolled activation and proliferation of T‐lymphocytes, leading to excessive …

ROTAVIRUS NONSTRUCTURAL PROTEIN 4 (NSP4) en-coded by gene 10 is the first
described viral enterotoxin (7). Since the report of the NSP4 toxic activity, identification of …

Rotavirus is a major cause of infantile viral gastroenteritis. Rotavirus nonstructural protein 4
(NSP4) has pleiotropic properties and functions in viral morphogenesis as well as …

Viroporins are virally encoded transmembrane proteins that are essential for viral
pathogenicity and can participate in various stages of the viral life cycle, thereby promoting …

Many viruses that replicate in the cytoplasm dramatically remodel and stimulate the
accumulation of host cell membranes for efficient replication by poorly understood …