To thrive and to fulfill their functions, cells need to maintain proteome homeostasis even in
the face of adverse environmental conditions or radical restructuring of the proteome during …

Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …

The mitochondrial unfolded protein response (UPRmt) is essential to safeguard
mitochondria from proteotoxic damage by activating a dedicated transcriptional response in …

Ribosome biogenesis is among the most resource-intensive cellular processes, with
ribosomal proteins accounting for up to half of all newly synthesized proteins in eukaryotic …

Stresses such as heat shock trigger the formation of protein aggregates and the induction of
a disaggregation system composed of molecular chaperones. Recent work reveals that …

Cells must sense and respond to sudden maladaptive environmental changes—stresses—
to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved …

Cellular homeostasis is continuously challenged by damage from reactive oxygen species
(ROS) and numerous reactive electrophiles. Human cells contain various protective systems …

Aging results in a decline of cellular proteostasis capacity which culminates in the
accumulation of phototoxic material, causing the onset of age-related maladies and …

Detailed understanding of the mechanism by which Hsp70 chaperones protect cells against
protein aggregation is hampered by the lack of a comprehensive characterization of the …

Mammalian developmental and disease-associated genes concentrate large quantities of
the transcriptional machinery by forming membrane-less compartments known as …