Background Participant retention strategies that minimise attrition in longitudinal cohort
studies have evolved considerably in recent years. This study aimed to assess, via …

Many factors contribute to human tooth loss, including oral hygiene practices, trauma,
smoking, health status, socio‐economic status and individual preferences. Loss of teeth …

Abstract FOXO1A and FOXO3A are two members of the FoxO family. FOXO3A has recently
been linked to human longevity in Japanese, German and Italian populations. Here we …

OBJECTIVES: To compare the risk of mortality of nonagenarian siblings with that of sporadic
nonagenarians (not selected on having a nonagenarian sibling) and to compare the …

The role of epigenetics in the modulation of longevity has not been studied in humans. To
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …

After a brief introduction to the background, significance and unique features of the
centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity …

Although the incidence of dementia increases exponentially with age, some individuals
reach more than 100 years with fully retained cognitive abilities. To identify the …

Globally, the lifespan of populations increases but the healthspan is lagging behind.
Previous research showed that survival into extreme ages (longevity) clusters in families as …

Centenarians' offspring represent a suitable model to study age-dependent variables (eg
IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was …

Mechanisms underlying the variation in human life expectancy are largely unknown, but
lipid metabolism and especially lipoprotein size was suggested to play an important role in …