Cannabinoids: therapeutic use in clinical practice

C Pagano, G Navarra, L Coppola, G Avilia… - International journal of …, 2022 - mdpi.com
Medical case reports suggest that cannabinoids extracted from Cannabis sativa have
therapeutic effects; however, the therapeutic employment is limited due to the psychotropic …

Anti-inflammatory and antiviral effects of cannabinoids in inhibiting and preventing SARS-CoV-2 infection

M Janecki, M Graczyk, AA Lewandowska… - International journal of …, 2022 - mdpi.com
The COVID-19 pandemic caused by the SARS-CoV-2 virus made it necessary to search for
new options for both causal treatment and mitigation of its symptoms. Scientists and …

The SARS-CoV-2 cytopathic effect is blocked by lysosome alkalizing small molecules

K Gorshkov, CZ Chen, R Bostwick… - ACS infectious …, 2020 - ACS Publications
Understanding the SARS-CoV-2 virus' pathways of infection, virus–host–protein interactions,
and mechanisms of virus-induced cytopathic effects will greatly aid in the discovery and …

Cannabinoids as key regulators of inflammasome signaling: a current perspective

SV Suryavanshi, I Kovalchuk, O Kovalchuk - Frontiers in immunology, 2021 - frontiersin.org
Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect
microbial materials, sterile inflammatory insults, and certain host-derived elements …

β-Caryophyllene, a natural dietary CB2 receptor selective cannabinoid can be a candidate to target the trinity of infection, immunity, and inflammation in Covid-19

NK Jha, C Sharma, HM Hashiesh… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease (COVID-19), caused by novel severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is an ongoing pandemic and presents a public health …

A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19

RL Chapman, SV Andurkar - Medicinal Chemistry Research, 2022 - Springer
During the COVID-19 pandemic lasting now for well more than a year, nearly 247 million
cases have been diagnosed and over 5 million deaths have been recorded worldwide as of …

Opportunities, challenges and pitfalls of using cannabidiol as an adjuvant drug in COVID-19

B Malinowska, M Baranowska-Kuczko… - International journal of …, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may lead to
coronavirus disease 2019 (COVID-19) which, in turn, may be associated with multiple organ …

Machine learning and network medicine approaches for drug repositioning for COVID-19

S de Siqueira Santos, M Torres, D Galeano… - Patterns, 2022 - cell.com
We present two machine learning approaches for drug repurposing. While we have
developed them for COVID-19, they are disease-agnostic. The two methodologies are …

A scarless healing tale: comparing homeostasis and wound healing of oral mucosa with skin and oesophagus

D Pereira, I Sequeira - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Epithelial tissues are the most rapidly dividing tissues in the body, holding a natural ability
for renewal and regeneration. This ability is crucial for survival as epithelia are essential to …

Cannabinoids as immune system modulators: Cannabidiol potential therapeutic approaches and limitations

A Aziz, LC Nguyen, L Oumeslakht… - Cannabis and …, 2023 - liebertpub.com
Introduction: Cannabidiol (CBD) is the second most abundant Phytocannabinoid in
Cannabis extracts. CBD has a binding affinity for several cannabinoid and cannabinoid …