Structure, function, signaling pathways and clinical therapeutics: The translational potential of STAT3 as a target for cancer therapy
D Shi, J Tao, S Man, N Zhang, L Ma, L Guo… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Cancer remains one of the most difficult human diseases to overcome because of its
complexity and diversity. Signal transducers and transcriptional activators 3 (STAT3) protein …
complexity and diversity. Signal transducers and transcriptional activators 3 (STAT3) protein …
New emerging targets in osteosarcoma therapy: PTEN and PI3K/Akt crosstalk in carcinogenesis
M Sadrkhanloo, MDA Paskeh, M Hashemi… - … -Research and Practice, 2023 - Elsevier
Osteosarcoma (OS) is a malignant bone carcinoma that affects people in childhood and
adulthood. The heterogeneous nature and chromosomal instability represent certain …
adulthood. The heterogeneous nature and chromosomal instability represent certain …
Farnesoid X receptor promotes non-small cell lung cancer metastasis by activating Jak2/STAT3 signaling via transactivation of IL-6ST and IL-6 genes
X Jin, B Shang, J Wang, J Sun, J Li, B Liang… - Cell Death & …, 2024 - nature.com
Metastasis accounts for the majority of cases of cancer recurrence and death in patients with
advanced non-small cell lung cancer (NSCLC). Farnesoid X Receptor (FXR) is a bile acid …
advanced non-small cell lung cancer (NSCLC). Farnesoid X Receptor (FXR) is a bile acid …
Maternal Exposure to Endocrine-Disrupting Chemicals: Analysis of Their Impact on Infant Gut Microbiota Composition
M Vacca, FM Calabrese, F Loperfido, B Maccarini… - Biomedicines, 2024 - mdpi.com
Endocrine disruptors (EDCs) are chemicals that interfere with the endocrine system. EDC
exposure may contribute to the development of obesity, type 2 diabetes, and cardiovascular …
exposure may contribute to the development of obesity, type 2 diabetes, and cardiovascular …
[HTML][HTML] The marine natural product trichobotrysin B inhibits proliferation and promotes apoptosis of human glioma cells via the IL-6-mediated STAT3/JAK signaling …
X Dai, J Fan, D Liu, H Li, L Shu, P Gao, S Chen… - Smart Materials in …, 2024 - Elsevier
Glioma is the most common malignant tumor of the central nervous system. Drug-assisted
chemotherapy is an important adjuvant treatment post-surgery, but currently, effective …
chemotherapy is an important adjuvant treatment post-surgery, but currently, effective …
High expression of DLGAP5 indicates poor prognosis and immunotherapy in lung adenocarcinoma and promotes proliferation through regulation of the cell cycle
X Tang, H Zhou, Y Liu - Disease Markers, 2023 - Wiley Online Library
Background. Lung adenocarcinoma (LUAD) is one of the most common types of cancer in
the respiratory system, with a high mortality and recurrence rate. The role of disc large …
the respiratory system, with a high mortality and recurrence rate. The role of disc large …
DLGAP5 Regulates the Proliferation, Migration, Invasion, and Cell Cycle of Breast Cancer Cells via the JAK2/STAT3 Signaling Axis
Y Li, J Wei, Y Sun, W Zhou, X Ma, J Guo… - International Journal of …, 2023 - mdpi.com
The aim of this study was to discover new biomarkers to detect breast cancer (BC), which is
an aggressive cancer with a high mortality rate. In this study, bioinformatic analyses …
an aggressive cancer with a high mortality rate. In this study, bioinformatic analyses …
Quercetin exerts anti-tumor immune mechanism by regulating IL-6/JAK2/STAT3 signaling pathway to deplete Treg cells
Y Liao, X Xie, C Zhang, H Zhong, L Shan, P Yu, L Xu - Toxicon, 2024 - Elsevier
Breast cancer is still the leading cause of death among women worldwide. Due to the lack of
effective drug targets, triple-negative breast cancer has a worse prognosis and higher …
effective drug targets, triple-negative breast cancer has a worse prognosis and higher …
DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1 and serves as a therapeutic target
M Chen, S Zhang, F Wang, J He, W Jiang… - Journal of Translational …, 2024 - Springer
Background Human discs large-associated protein 5 (DLGAP5) is reported to play a pivotal
role in regulating the cell cycle and implicate in tumorigenesis and progression of various …
role in regulating the cell cycle and implicate in tumorigenesis and progression of various …
HOXB5 promotes the progression and metastasis of osteosarcoma cells by activating the JAK2/STAT3 signalling pathway
Q Ma, X Li, H Wang, S Xu, Y Que, P He, R Yang… - Heliyon, 2024 - cell.com
Objective To investigate the involvement of the homeobox gene B5 (HOXB5) in the
progression and metastasis of osteosarcoma. Methods The expression of HOXB5 in human …
progression and metastasis of osteosarcoma. Methods The expression of HOXB5 in human …