Hyperprolactinaemia

I Samperi, K Lithgow, N Karavitaki - Journal of clinical medicine, 2019 - mdpi.com
Hyperprolactinaemia is one of the most common problems in clinical endocrinology. It
relates with various aetiologies (physiological, pharmacological, pathological), the …

Hyperprolactinemia: pathophysiology and therapeutic approach

A Capozzi, G Scambia, A Pontecorvi… - Gynecological …, 2015 - Taylor & Francis
Prolactin (PRL) is a hormone, mainly secreted by lactotroph cells of the anterior pituitary
gland. Recent studies have shown it may also be produced by many extrapituitary cells. Its …

Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner

NK Neradugomma, D Subramaniam, OW Tawfik… - …, 2014 - academic.oup.com
Prolactin (PRL) is a secretory cytokine produced by various tissues. Binding to the cognate
PRL receptor (PRLR), it activates intracellular signaling via janus kinase (JAK), extracellular …

A novel model of cancer drug resistance: oncosomal release of cytotoxic and antibody-based drugs

T Eguchi, EA Taha, SK Calderwood, K Ono - Biology, 2020 - mdpi.com
Extracellular vesicles (EVs), such as exosomes or oncosomes, often carry oncogenic
molecules derived from tumor cells. In addition, accumulating evidence indicates that tumor …

Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium

RT Fortner, EM Poole, NA Wentzensen… - … journal of cancer, 2019 - Wiley Online Library
Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial
variability in outcomes. We hypothesized that risk factor profiles may influence tumor …

Fallopian tube initiation of high grade serous ovarian cancer and ovarian metastasis: Mechanisms and therapeutic implications

TM Bergsten, JE Burdette, M Dean - Cancer letters, 2020 - Elsevier
Ovarian cancer is the most lethal gynecologic malignancy and the fifth leading cause of
cancer-related death in women. Although outcomes have improved in recent years, there …

[HTML][HTML] Prolactin drives iron release from macrophages and uptake in mammary cancer cells through CD44

R Farrell, N Pascuzzi, YL Chen, M Kim… - International Journal of …, 2024 - mdpi.com
Iron is an essential element for human health. In humans, dysregulated iron homeostasis
can result in a variety of disorders and the development of cancers. Enhanced uptake …

Efficacy and safety profiles of mood stabilizers and antipsychotics for bipolar depression: a systematic review

L Cai, G Chen, H Yang, Y Bai - International Clinical …, 2023 - journals.lww.com
The whole picture of psychotropics for bipolar depression (BPD) remains unclear. This
review compares the differences in efficacy and safety profiles among common …

Breastfeeding and the risk of epithelial ovarian cancer among women with a BRCA1 or BRCA2 mutation

J Kotsopoulos, J Gronwald, JM McCuaig, BY Karlan… - Gynecologic …, 2020 - Elsevier
Objective BRCA mutation carriers face a high lifetime risk of developing ovarian cancer. The
strong inverse association between breastfeeding and the risk of ovarian cancer is …

Connections between prolactin and ovarian cancer

A Alkharusi, A AlMuslahi, N AlBalushi, R AlAjmi… - PLoS …, 2021 - journals.plos.org
Ovarian cancer (OC) is characterized by a high morbidity and mortality, highlighting a great
need for a better understanding of biological mechanisms that affect OC progression and …