Applications and evolution of melittin, the quintessential membrane active peptide
Melittin, the main venom component of the European Honeybee, is a cationic linear peptide-
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …
Mechanistic landscape of membrane-permeabilizing peptides
Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …
Mechanism matters: a taxonomy of cell penetrating peptides
The permeability barrier imposed by cellular membranes limits the access of exogenous
compounds to the interior of cells. Researchers and patients alike would benefit from …
compounds to the interior of cells. Researchers and patients alike would benefit from …
Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials
Antimicrobial peptides (AMPs) which predominantly act via membrane active mechanisms
have emerged as an exciting class of antimicrobial agents with tremendous potential to …
have emerged as an exciting class of antimicrobial agents with tremendous potential to …
Synthetic molecular evolution of antimicrobial peptides
Highlights•Various peptide design methods have facilitated peptide–drug
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …
Database-guided discovery of potent peptides to combat HIV-1 or superbugs
G Wang - Pharmaceuticals, 2013 - mdpi.com
Antimicrobial peptides (AMPs), small host defense proteins, are indispensable for the
protection of multicellular organisms such as plants and animals from infection. The number …
protection of multicellular organisms such as plants and animals from infection. The number …
Synthetic molecular evolution of hybrid cell penetrating peptides
Peptides and analogs such as peptide nucleic acids (PNA) are promising tools and
therapeutics, but the cell membrane remains a barrier to intracellular targets. Conjugation to …
therapeutics, but the cell membrane remains a barrier to intracellular targets. Conjugation to …
Host cell interactions are a significant barrier to the clinical utility of peptide antibiotics
Despite longstanding promise and many known examples, antimicrobial peptides (AMPs)
have failed, thus far, to impact human medicine. On the basis of the physical chemistry and …
have failed, thus far, to impact human medicine. On the basis of the physical chemistry and …
DNA scaffolds support stable and uniform peptide nanopores
The assembly of peptides into membrane-spanning nanopores might be promoted by
scaffolds to pre-organize the structures. Such scaffolds could enable the construction of …
scaffolds to pre-organize the structures. Such scaffolds could enable the construction of …
Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria
Novel classes of antibiotics and new strategies to prevent and treat infections are urgently
needed because the rapid rise in drug-resistant bacterial infections in recent decades has …
needed because the rapid rise in drug-resistant bacterial infections in recent decades has …