The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians,
researchers, policymakers, politicians and the public at large. The evolution and widespread …

Highlights•Phages drive horizontal gene transfer between prokaryotes.•Lysogenic
conversion provides novel adaptive traits, at the cost of eventual lysis.•Prophages account …

Mycobacteriophages—bacteriophages infecting Mycobacterium hosts—contribute
substantially to our understanding of viral diversity and evolution, provide resources for …

Infections caused by antibiotic-resistant bacteria are a rising public health threat and make
the identification of new antibiotics a priority. From a cell-based screen for bactericidal …

The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of …

The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

Summary The ClpC1: ClpP1P2 protease is a core component of the proteostasis system in
mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease …

The recent discovery of small molecules targeting the cytochrome bc 1: aa 3 in
Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for …

Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS),
designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best …

Pyroptosis, an inflammatory form of programmed cell death, has been implicated in
eliminating pathogenic infections. However, macrophage pyroptosis–related proteins from …