The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic
activity is one of the important inducements for bacteria to develop drug resistance. Bacteria …

The emergence and the dissemination of multidrug-resistant bacteria constitute a major
public health issue. Among incriminated Gram-negative bacteria, Pseudomonas aeruginosa …

Quorum sensing (QS) inhibition is one of the potential methods to target bacterial infection.
In this study, comprehensive molecular dynamics simulation (MDS) experiments were …

Pathogenic bacteria use an intercellular chemical communication system called quorum
sensing (QS) to control the expression of cellular functions such as virulence factors, biofilm …

Introduction: Persistent infections caused by the superbug Pseudomonas aeruginosa and its
resistance to multiple antimicrobial agents are huge threats to patients with cystic fibrosis as …

Antibiotic resistance is one of the most important challenges of the 21st century. However,
the growing understanding of bacterial pathogenesis and cell-to-cell communication has …

As bacteria continue to develop resistance mechanisms against antimicrobials, an
alternative method to tackle this global concern must be developed. As the pqs system is the …

The antibiotic crisis is associated with the appearance of multidrug resistant (MDR)
pathogens, which has caused severe bacterial infections and imposed a huge burden on …

In this study, we report the chemical synthesis, computational analysis, and anti‐virulent
studies of five Vanillin‐based hybrids employing phytochemicals. Vanillin (V) is known to …

Triazole, sulfonamide and sulfonyl urea derivatives of N-acylhomoserine lactones (AHLs)
have been prepared from homoserine lactone hydrobromide which in turn is derived from l …