Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …

Superoxide is a primary oxygen radical that is produced when an oxygen molecule receives
one electron. Superoxide dismutase (SOD) plays a primary role in the cellular defense …

Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …

Senescent cell accumulation has been implicated in the pathogenesis of aging-associated
diseases, including cancer. The mechanism that prevents the accumulation of senescent …

In the present review, we describe the causes and consequences of loss of vascular smooth
muscle cells (VSMCs) or their function in advanced atherosclerotic plaques and discuss …

Cells continually experience stress and damage from exogenous and endogenous sources,
and their responses range from complete recovery to cell death. Proliferating cells can …

Although older age is the greatest risk factor for osteoarthritis (OA), OA is not an inevitable
consequence of growing old. Radiographic changes of OA, particularly osteophytes, are …

Abstract The terms 'antioxidant','oxidative stress' and 'oxidative damage'are widely used but
rarely defined. This brief review attempts to define them and to examine the ways in which …

The skin is comprised of different cell types with different proliferative capacities. Skin aging
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …

The prevalence of osteoarthritis (OA) increases with age such that 30% to 50% of adults
older than 65 years suffer from this condition. 1, 2 Radiographic changes of OA, in particular …